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Cat. No.	Product Name	Target	Signaling Pathways
T7752	(S,R,S)-AHPC-Me VHL ligand 2,E3 ligase Ligand 1A	Ligand for E3 Ligase	PROTAC
	(S,R,S)-AHPC-Me (E3 ligase Ligand 1A) 是基于 (S,R,S)-AHPC 的的 VHL 配体，可用于募集 von Hippel-Lindau (VHL) 蛋白。它可有效降解去势抵抗性前列腺癌细胞中的 BET 蛋白，DC50<1 nM。它可用于合成 ARV-771。
T13671	(S,R,S)-AHPC-Me hydrochloride VHL ligand 2 hydrochloride,E3 ligase Ligand 1	Others; Ligand for E3 Ligase	Others; PROTAC
	(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is a chemical compound utilized in the synthesis of ARV-771, an exceptionally potent BET protein degrader. This compound selectively degrades BET protein in cells resistant to castration, exhibiting a remarkable DC50 <1 nM. Recognized as VHL ligand 2 hydrochloride, (S,R,S)-AHPC-Me hydrochloride serves as the VHL ligand derived from (S,R,S)-AHPC for the recruitment of von Hippel-Lindau (VHL) protein.
T17924	(S,R,S)-AHPC-PEG2-NH2 hydrochloride VH032-PEG2-NH2 hydrochloride,VHL Ligand-Linker Conjugates 3 hydrochloride,E3 ligase Ligand-Linker Conjugates 6	Others; E3 Ligase Ligand-Linker Conjugate	Others; PROTAC
	(S,R,S)-AHPC-PEG2-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 6) 包含基于 (S,R,S)-AHPC 的 VHL 配体和 2 个单元 PEG linker，是一种合成的 E3 连接酶配体-linker 偶联物，可用于 PROTAC 的合成分子。
T13671L	(S,R,S)-AHPC-Me dihydrochloride VHL ligand 2 dihydrochloride,E3 ligase Ligand 1 dihydrochloride,(S,R,S)-AHPC-Me dihydrochloride (1948273-02-6 free base)	Others	Others
	(S,R,S)-AHPC-Me dihydrochloride, also known as VHL ligand 2 dihydrochloride, is a chemical compound utilized in the synthesis of ARV-771. ARV-771, a BET PROTAC degrader relying on von Hippel-Landau (VHL) E3 ligase, demonstrates potent degradation of BET protein in castration-resistant prostate cancer (CRPC) cells, with a DC50 of less than 1 nM. This compound serves as the VHL ligand, specifically the (S,R,S)-AHPC-based VHL ligand, that facilitates the recruitment of von Hippel-Lindau (VHL) prote...
T17905	(S,R,S)-AHPC-PEG1-OTs VH032-PEG1-OTs,VHL Ligand-Linker Conjugates 2,E3 ligase Ligand-Linker Conjugates 51	Others	Others
	(S,R,S)-AHPC-PEG1-OTs is a chemically synthesized conjugate, functioning as an ligase ligand-linker for E3 ligase. It incorporates the VHL ligand derived from (S,R,S)-AHPC and a 1-unit PEG linker. This synthesized compound is commonly employed in PROTAC technology.
T17912	(S,R,S)-AHPC-(C3-PEG)2-C6-Cl VHL Ligand-Linker Conjugates 11,E3 ligase Ligand-Linker Conjugates 11	Others	Others
	(S,R,S)-AHPC-(C3- PEG) 2- C6- Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-(C3- PEG) 2- C6- Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].
T17913	(S,R,S)-AHPC-PEG2-N3 VHL Ligand-Linker Conjugates 6,VH032-PEG2-N3,E3 ligase Ligand-Linker Conjugates 13	Others; Ligand for E3 Ligase	Others; PROTAC
	(S,R,S)-AHPC-PEG2-N3 (VHL Ligand-Linker Conjugates 6) 包含基于 (S,R,S)-AHPC 的 VHL 配体和 2 个单元 PEG linker，是一种合成的 E3 连接酶配体-linker 偶联物。
T17910	(S,R,S)-AHPC-PEG2-C4-Cl E3 ligase Ligand-Linker Conjugates 10,VHL Ligand-Linker Conjugates 7,VH032-PEG2-C4-Cl	Others	Others
	(S,R,S)-AHPC-PEG2-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-PEG2-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].
T17925	(S,R,S)-AHPC-PEG2-NH2 VH032-PEG2-NH2,VHL Ligand-Linker Conjugates 3,E3 ligase Ligand-Linker Conjugates 6 Free Base	Others; E3 Ligase Ligand-Linker Conjugate	Others; PROTAC
	(S,R,S)-AHPC-PEG2-NH2 (VHL Ligand-Linker Conjugates 3) 包含基于 (S,R,S)-AHPC 的 VHL 配体和 2 个单元 PEG linker，是一种合成的 E3 连接酶配体-linker 偶联物。可用于 PROTAC 的合成分子。
T18675	(S,R,S)-AHPC-PEG2-NH2 dihydrochloride VH032 amide-PEG2-amine,VH032-PEG2-NH2 dihydrochloride,(S,R,S)-AHPC-PEG2-NH2二盐酸盐,VH032-linker 12	Others; Ligand for E3 Ligase	Others; PROTAC
	(S,R,S)-AHPC-PEG2-NH2 dihydrochloride (VH032-linker 12) 包含基于 (S,R,S)-AHPC 的 VHL 配体和 2 个单元 PEG linker，是一种合成的 E3 连接酶配体-linker 偶联物，可用于 PROTAC 分子的合成。
T17996	VH032-PEG5-C6-Cl HaloPROTAC 2	Others	Others
	VH032-PEG5-C6-Cl (HaloPROTAC 2) is a small molecule HaloPROTAC that incorporates the VH032 based VHL ligand and 5-unit PEG linker. VH032-PEG5-C6-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].
T18668	(S,R,S)-AHPC-Me-C10-Br	Others	Others
	(S,R,S)-AHPC-Me-C10-Br is a chemically synthesized conjugate that functions as a ligand-linker for E3 ligases. This compound incorporates a VHL E3 ligase linker and MS432, derived from the MEK1/2 inhibitor PD0325901[1].
T40217	PD0325901-O-C2-dioxolane PD0325901-O-C2-dioxolane
	PD0325901-O-C2-dioxolane is a chemical compound primarily composed of the MEK inhibitor PD0325901. It can be utilized, in conjunction with either a VHL or CRBN E3 ligase ligand, for the synthesis of MEK1/2 degrader.
T73945	MAK683-CH2CH2COOH hydrochloride
	MAK683-CH2CH2COOH 与 EED (胚胎外胚层发育蛋白) 结合。MAK683-CH2CH2COOH 和 E3 泛素连接酶的 VHL 配体设计了 PROTACEED degrader-1 和 PROTACEED degrader-2 。
T36267	VH 032 amide-PEG4-amine VH 032 amide-PEG4-amine
	Functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC research and development; incorporates an E3 ligase ligand plus a PEG linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. This product has been recently renamed. The previous name for this product was VH 032 - linker 2 PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.
T18055	K-Ras ligand-Linker Conjugate 2	Others	Others
	K-Ras ligand-Linker Conjugate 2 is a chemical compound that includes a ligand for K-Ras and a PROTAC linker. This compound is capable of recruiting E3 ligases like VHL, CRBN, MDM2, and IAP. It is utilized in the synthesis of PROTAC K-Ras Degrader-1, which is a highly effective PROTAC K-Ras degrader with a degradation efficacy of ≥70% in SW1573 cells[1].
T13765	MAK683-CH2CH2COOH	Others	Others
	MAK683-CH2CH2COOH 与 EED (胚胎外胚层发育蛋白) 结合。基于MAK683-CH2CH2COOH 和 E3 泛素连接酶的 VHL 配体，设计了靶向EED 的PROTACs， PROTAC EED degrader-1 和 PROTAC EED degrader-2 。
T36270	(S,R,S)-AHPC-phenol-alkylC6-amine dihydrochloride VH 032 phenol-alkylC6-amine
	Functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC research and development; incorporates an E3 ligase ligand plus an alkyl linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. This product has been recently renamed. The previous name for this product was VH 032 phenol - linker 2 PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

化合物

(S,R,S)-AHPC-Me

Cat.No: T7752

Synonym: VHL ligand 2,E3 ligase Ligand 1A

Target: Ligand for E3 Ligase

(S,R,S)-AHPC-Me hydrochloride

Cat.No: T13671

Synonym: VHL ligand 2 hydrochloride,E3 ligase Ligand 1

Target: Others, Ligand for E3 Ligase

(S,R,S)-AHPC-PEG2-NH2 hydrochloride

Cat.No: T17924

Synonym: VH032-PEG2-NH2 hydrochloride,VHL Ligand-Linker Conjugates 3 hydrochloride,E3 ligase Ligand-Linker Conjugates 6

Target: Others, E3 Ligase Ligand-Linker Conjugate

(S,R,S)-AHPC-Me dihydrochloride

Cat.No: T13671L

Synonym: VHL ligand 2 dihydrochloride,E3 ligase Ligand 1 dihydrochloride,(S,R,S)-AHPC-Me dihydrochloride (1948273-02-6 free base)

Target: Others

(S,R,S)-AHPC-PEG1-OTs

Cat.No: T17905

Synonym: VH032-PEG1-OTs,VHL Ligand-Linker Conjugates 2,E3 ligase Ligand-Linker Conjugates 51

Target: Others

(S,R,S)-AHPC-(C3-PEG)2-C6-Cl

Cat.No: T17912

Synonym: VHL Ligand-Linker Conjugates 11,E3 ligase Ligand-Linker Conjugates 11

Target: Others

(S,R,S)-AHPC-PEG2-N3

Cat.No: T17913

Synonym: VHL Ligand-Linker Conjugates 6,VH032-PEG2-N3,E3 ligase Ligand-Linker Conjugates 13

Target: Others, Ligand for E3 Ligase

(S,R,S)-AHPC-PEG2-C4-Cl

Cat.No: T17910

Synonym: E3 ligase Ligand-Linker Conjugates 10,VHL Ligand-Linker Conjugates 7,VH032-PEG2-C4-Cl

Target: Others

(S,R,S)-AHPC-PEG2-NH2

Cat.No: T17925

Synonym: VH032-PEG2-NH2,VHL Ligand-Linker Conjugates 3,E3 ligase Ligand-Linker Conjugates 6 Free Base

Target: Others, E3 Ligase Ligand-Linker Conjugate

(S,R,S)-AHPC-PEG2-NH2 dihydrochloride

Cat.No: T18675

Synonym: VH032 amide-PEG2-amine,VH032-PEG2-NH2 dihydrochloride,(S,R,S)-AHPC-PEG2-NH2二盐酸盐,VH032-linker 12

Target: Others, Ligand for E3 Ligase

VH032-PEG5-C6-Cl

Cat.No: T17996

Synonym: HaloPROTAC 2

Target: Others

(S,R,S)-AHPC-Me-C10-Br

Cat.No: T18668

Target: Others

PD0325901-O-C2-dioxolane

Cat.No: T40217

Synonym: PD0325901-O-C2-dioxolane

MAK683-CH2CH2COOH hydrochloride

Cat.No: T73945

VH 032 amide-PEG4-amine

Cat.No: T36267

Synonym: VH 032 amide-PEG4-amine

K-Ras ligand-Linker Conjugate 2

Cat.No: T18055

Target: Others

MAK683-CH2CH2COOH

Cat.No: T13765

Target: Others

(S,R,S)-AHPC-phenol-alkylC6-amine dihydrochloride

Cat.No: T36270

Synonym: VH 032 phenol-alkylC6-amine

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